Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis
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- 作者：Endrawan Pratamaa ; Xiaohui Tianb ; Widya Lestaric ; Sachiko Isekia ; Solachuddin J.A. Ichwanc ; Masa-Aki Ikedaa ; mikeda.emb@tmd.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ARID3A ; ARID3B ; p53 ; Gene expression ; Apoptosis
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2015
- 出版时间：4-11 December 2015
- 年：2015
- 卷：468
- 期：1-2
- 页码：248-254
- 全文大小：1374 K
文摘
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ARID3A and ARID3B bind to ARID3-binding sites in the p53 target genes.
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ARID3B silencing blocked expression of pro-apoptotic p53-target genes.
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ARID3B overexpression activated transcription of pro-apoptotic p53-target genes.
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Ectopic ARID3B but not ARID3A expression induced apoptosis.
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ARID3B but not ARID3A silencing blocked apoptosis following DNA damage.