The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression
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- 作者：Yong-Ku Kima ; Kyoung-Sae Nab ; ksna13@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Aye-Mu Myintc ; Brian E. Leonardd ; e
- 关键词：MDD ; major depressive disorder ; GR ; glucocorticoid receptor ; IL-1尾 ; interleukin-1尾 ; IL-6 ; interleukin-6 ; TNF-伪 ; tumor necrosis factor-伪 ; IL-4 ; interleukin-4 ; IL-10 ; interleukin-10 ; CNS ; central nervous system ; BBB ; blood&ndash ; brain barrier ; IL-2 ; interleukin-2 ; IFN-纬 ; interferon-纬 ; IFN-伪 ; interferon-伪 ; HPA ; hypothalamus&ndash ; pituitary&ndash ; adrenal ; CRH ; corticotropin-releasing hormone ; ACTH ; adrenocorticotropic hormone ; MR ; mineralocorticoid receptor ; NF-魏B ; nuclear factor-魏B ; MAPK ; mitogen-a
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：4 January 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：277-284
- 全文大小：566 K
文摘
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Cytokines play an important role in the neuroinflammatory responses in depression.
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Neuroinflammation and glucocorticoid receptor dysfunction create a vicious cycle.
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Chronic increases in pro-inflammatory cytokines and glucocorticoids exert detrimental effects on the hippocampus.