Difluorosialic acids, potent novel influenza virus neuraminidase inhibitors, induce fewer drug resistance-associated neuraminidase mutations than does oseltamivir
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- 作者：S.-H. Sheldon Taia ; Olga Agafiteia ; Zhizeng Gaob ; Richard Ligginsc ; Martin Petricd ; Stephen G. Withersb ; Masahiro Niikuraa ; niikura@sfu.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：DFSA ; difluorosialic acid ; ED50 ; median effective dose ; FeqGuDFSA ; 5-Acetamido-3 ; 4 ; 5-trideoxy-2α ; 3β-difluoro-4-guanidino-α-d-erythro-l-glucononulopyranosonate ; HA ; hemagglutinin ; IC50 ; half maximal inhibitory concentration ; IFV ; influenza virus ; IFV-A ; influenza A virus ; NA ; neuraminidase ; NAI ; neuraminidase inhibitor
- 刊名：Virus Research
- 出版年：2015
- 出版时间：2 December 2015
- 年：2015
- 卷：210
- 期：Complete
- 页码：126-132
- 全文大小：1191 K
文摘
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Difluorosialic acids (DFSAs) are a novel class of anti-IFV NAIs.
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We evaluated the propensity of IFV-A NA to develop resistance against the DFSA.
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We generated 15 apparently DFSA-resistant influenza mutant lines in vitro.
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None of these 15 DFSA-selected viruses contained DFSA-resistant NA mutation.
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DFSA induced fewer drug resistance-associated NA mutations than did oseltamivir.