Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine
详细信息 查看全文
- 作者：Jorge Vicente-Baz ; Jose A. Lopez-Garcia ; Ivan Rivera-Arconada ; ivan.rivera@uah.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：ML213 ; ICA-069673 ; KCNQ channels ; M-current ; Pain
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：109
- 期：Complete
- 页码：131-138
- 全文大小：1400 K
文摘
- •
Retigabine, ICA-069673 and ML213 reduced nociceptive reflexes to a similar extent.
- •
ML213 showed a higher potency than the other compounds.
- •
Unlike retigabine, ML213 and ICA-069673 affected non-nociceptive transmission.
- •
Retigabine had nonspecific effects at high concentrations.
- •
All effects of ICA-069673 and ML213 appear to be mediated specifically by Kv7 channels.