An Essential Mesenchymal Function for miR-143/145 in Intestinal Epithelial Regeneration
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- 作者：Raghu R. Chivukula1 ; 6 ; Guanglu Shi2 ; 6 ; Asha Acharya2 ; Eric W. Mills1 ; Lauren R. Zeitels1 ; Joselin L. Anandam3 ; Abier A. Abdelnaby3 ; Glen C. Balch3 ; John C. Mansour3 ; Adam C. Yopp3 ; Anirban Maitra4 ; Joshua T. Mendell2 ; 5 ; joshua.mendell@utsouthwestern.edu" class="auth_mail
- 刊名：Cell
- 出版年：22 May 2014
- 年：2014
- 卷：157
- 期：5
- 页码：1104-1116
- 全文大小：4588 K
文摘
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miR-143/145 are essential for mouse intestinal epithelial regeneration after injury
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miR-143/145 expression and function are restricted to the intestinal mesenchyme
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Upregulated IGFBP5 and reduced IGF signaling correlate with regenerative failure
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Results challenge a cell-autonomous tumor suppressor role for miR-143/145 in colon