Experimental study on gastroprotective efficacy and mechanisms of luteolin-7-O-glucoside isolated from Ophiorrhiza mungos Linn. in different experimental models
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- 作者：Paulrayer Antonisamy<sup>asup> ; Pandurangan Subash-Babu<sup>bsup> ; Arul Albert-Baskar<sup>csup> ; Ali A. Alshatwi<sup>bsup> ; Adithan Aravinthan<sup>asup> ; Savarimuthu Ignacimuthu<sup>dsup> ; Ki Choon Choi<sup>esup> ; Sung Cheol Lee<sup>fsup> ; Jong-Hoon Kim<sup>asup><sup> ; sup><sup>jhkim1@jbnu.ac.kr" class="auth_mail" title="E-mail the corresponding authorsup>
- 关键词：Gastroprotective activity ; Ethanol-induced gastric injury ; Oxidative stress ; Apoptosis ; LUT7G ; Ophiorrhiza mungos
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：25
- 期：Complete
- 页码：302-313
- 全文大小：3465 K
文摘
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This is the first study to assess the efficiency of LUT7G against diverse gastric ulcer models.
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LUT7G shows significant gastroprotective activity.
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LUT7G pretreatment preserves normal gastric functions on ulcerated rats.
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Possible mechanisms were anti-inflammatory, antioxidant and anti-apoptotic actions.