New antimicrobial anthraquinone 6,6<sup>1sup>-bis (1,5,7-trihydroxy-3-hydroxymethylanthraquinone) isolated from Streptomyces sp. isolate ERI-26
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- 作者：V. Duraipandiyan<sup>asup><sup> ; sup><sup>bsup><sup> ; sup><sup>avdpandiyan@yahoo.co.in" class="auth_mail" title="E-mail the corresponding authorsup> ; Naif Abdullah Al-Dhabi<sup>asup> ; S. Ignacimuthu<sup>bsup><sup> ; sup><sup>csup>
- 关键词：Streptomyces sp. ; Antimicrobial ; 16s rRNA ; Anthraquinones ; NMR ; HPLC
- 刊名：Saudi Journal of Biological Sciences
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：23
- 期：6
- 页码：731-735
- 全文大小：530 K
文摘
The present report is about Streptomyces sp. isolate ERI-26 isolated from the soil sample of Nilgiri forest, Western Ghats. The methanol extract of ERI-26 showed good antimicrobial activity against tested microbes. The antimicrobial novel anthraquinones were purified by bioactivity-guided fractionation using a silica gel column and preparative HPLC. The compound was characterized and identified by UV, IR, NMR and MASS spectral data. The compound named as 6,6<sup>1sup>-bis (1,5,7-trihydroxy-3-hydroxymethylanthraquinone), showed significant antimicrobial activities against tested microbes. The isolated compound inhibited the tested bacterial growth, Staphylococcus aureus at 62.5 μg/ml, Staphylococcus epidermidis at 15.62 μg/m, Bacillus subtilis at 62.5 μg/ml, fungi; Trichophyton mentagrophytes at 15.62 μg/m Trichophyton simii at 15.62 μg/ml, Aspergillus niger at. 7.81 μg/ml, Aspergiller flavus at 3.90 μg/ml, Trichophyton rubrum 296 at 62.5 μg/ml, T. rubrum 57/01 at 7.81 μg/ml, Magnaporthe grisea at 15.62 μg/ml. and Botrytis cinerea at 3.90 μg/ml. Isolated anthraquinone compound and its antimicrobial activity were newly reported.