Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis
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- 作者：Mahesh S. Padanad1 ; 2 ; 12 ; Georgia Konstantinidou1 ; 2 ; 12 ; 13 ; Niranjan Venkateswaran1 ; 2 ; Margherita Melegari2 ; Smita Rindhe1 ; 2 ; Matthew Mitsche3 ; 4 ; Chendong Yang5 ; Kimberly Batten6 ; Kenneth E. Huffman7 ; Jingwen Liu8 ; Ximing Tang9 ; Jaime Rodriguez-Canales9 ; Neda Kalhor9 ; Jerry W. Shay6 ; John D. Minna1 ; 7 ; Jeffrey McDonald4 ; Ignacio I. Wistuba10 ; 11 ; Ralph J. DeBerardinis3 ; 5 ; Pier Paolo Scaglioni1 ; 2 ; pier.scaglioni@utsouthwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACSL3 ; mutant KRAS ; lung cancer ; cancer metabolism ; fatty acid oxidation ; lipid metabolism ; mouse cancer models
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：9 August 2016
- 年：2016
- 卷：16
- 期：6
- 页码：1614-1628
- 全文大小：5282 K
文摘
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ACSL3 expression and activity in lung cancer cells is upregulated by mutant KRAS
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ACSL3 suppression decreases β-oxidation and ATP levels in mutant KRAS lung cancer cells
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ACSL3 is required for survival and oncogenic capacity of mutant KRAS lung cancer cells
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ACSL3 is highly expressed in human lung cancer specimens and promotes cancer initiation