Enhancer Divergence and cis-Regulatory Evolution in the Human and Chimp Neural Crest
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- 作者：Sara L. Prescott1 ; Rajini Srinivasan1 ; Maria Carolina Marchetto2 ; Irina Grishina3 ; Iñ ; igo Narvaiza2 ; Licia Selleri3 ; Fred H. Gage2 ; 4 ; Tomek Swigut1 ; swigut@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; Joanna Wysocka1 ; 5 ; 6 ; wysocka@stanford.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2015
- 出版时间：24 September 2015
- 年：2015
- 卷：163
- 期：1
- 页码：68-83
- 全文大小：5977 K
文摘
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Aspects of higher primate embryogenesis can be recapitulated in vitro using iPSCs
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Epigenomic profiling from human and chimp CNCCs reveals divergent facial enhancers
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Recently diverging CNCC enhancers have distinct sequence features
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Species-biased enhancers cluster near loci affecting intra-human facial variation