High expression of the immature laminin receptor protein correlates with mutated IGVH status and predicts a favorable prognosis in chronic lymphocytic leukemia

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• 作者：Birte Friedrichs^a ; ^b ; ¹ ; ^{birte.friedrichs@charite.de"" rel=""nofollow} ; Sandra Siegel^a ; ¹ ; Rudolph Reimer^c ; Adel Barsoum^d ; Joseph Coggin Jr^d ; Dieter Kabelitz^e ; Klaus Heidorn^f ; Christoph Schulte^f ; Norbert Schmitz^a ; Matthias Zeis^a
• 关键词：Chronic lymphocytic leukemia ; Tumor antigen ; Immature laminin receptor ; IGVH mutational status ; Prognosis
• 刊名：Leukemia Research
• 出版年：2011
• 出版时间：June 2011
• 年：2011
• 卷：35
• 期：6
• 页码：721-729
• 全文大小：1380 K

文摘

The immature laminin receptor (iLR) is a tumor-associated antigen. We analyzed the expression of iLR on malignant B cells of 134 unselected patient samples with CLL and hypothesized that iLR expression would have prognostic significance due to a differential expression pattern. High ILR expression (cut-off value 30 % ) was correlated with mutated IGVH status (p < 0.0001). Patients with high iLR-expression had a significantly longer time to progression (p = 0.039). Combination of CD38, ZAP-70, and iLR by flow cytometry can be used to construct a diagnostic score identifying patients with a median progression free survival of 80 months, if no adverse marker is present.