ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca2 + signaling
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- 作者：Mart Bittremieuxa ; Jan B. Parysa ; Paolo Pintonb ; Geert Bultyncka ; geert.bultynck@med.kuleuven.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：a.a. ; amino acid ; ATP ; adenosine triphosphate ; BH domain ; Bcl-2-homology domain ; BI-1 ; Bax inhibitor-1 ; BIRD-2 ; Bcl-2/IP3R disruptor-2 ; BRCA1 ; breast and ovarian cancer susceptibility gene 1 ; [Ca2 ; +]cyt ; cytosolic Ca2 ; + concentration ; CLL ; chronic lymphocytic leukemia ; DL-BCL ; diffuse large B-cell lymphoma ; ER ; endoplasmic reticulum ; GAP ; GTPase-activating protein ; IICR ; IP3-induced Ca2 ; + release ; IP3R ; inositol 1 ; 4 ; 5-trisphosphate receptor ; MAM ; mitochondria-associated ER membran
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：1863
- 期：6
- 页码：1364-1378
- 全文大小：1364 K
文摘
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Altered intracellular Ca2 + signaling is a hallmark of cancer cells.
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Several oncogenes and tumor suppressors act at the endoplasmic reticulum, the main intracellular Ca2 + store.
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These proteins execute part of their functions through the modulation of intracellular Ca2 + homeostasis and dynamics.
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Dysregulation of oncogenes and tumor suppressors favors oncogenic Ca2 + signaling, supporting cell survival and tolerance to cell death.