14-3-3 regulates life span by both DAF-16-dependent and -independent mechanisms in Caenorhabditis elegans

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• 作者：Caroline Araiz ; Marie-Thé ; rè ; se Châ ; teau ; Simon Galas
• 关键词：C. elegans ; Ageing ; Insulin/IGF-1/DAF-2 ; FOXO/DAF-16 ; 14-3-3/ftt1/ftt2
• 刊名：Experimental Gerontology
• 出版年：2008
• 出版时间：June 2008
• 年：2008
• 卷：43
• 期：6
• 页码：505-519
• 全文大小：587 K

文摘

Caenorhabditis elegans life span, stress resistance and metabolism are regulated by the Insulin/IGF-1/DAF-2/DAF-16 pathway. DAF-16, a member of FOXO/Forkhead transcription factor family, can be targeted by 14-3-3 proteins to promote stress resistance. We have identified a 14-3-3 C. elegans homolog which promotes life span by both DAF-2-dependent and -independent mechanisms and by an unexpected DAF-16-independent mechanism. Our results demonstrate that C. elegans 14-3-3 proteins modulate stress-responsive genes throughout adulthood. In conclusion, 14-3-3 can be considered as an acute stress-responsive regulator as well as a sustained modulator of the Insulin/IGF-1/DAF-2/DAF-16 regulatory pathway in promoting life expectancy of growing old worms.