Ctenopharyngodon idella NF-κB subunit p65 modulates the transcription of IκBα in CIK cells
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- 作者：Haizhou Wanga ; b ; Youlin Zhua ; ; Xiaowen Xua ; Xiangqin Wanga ; Qunhao Houa ; Qun Xua ; Zhicheng Suna ; Yichuan Mia ; Chengyu Hua ; hucy2008@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：p65 ; NF-κB pathway ; IκB ; Transcriptional regulation ; Teleost fish
- 刊名：Fish & Shellfish Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：54
- 期：Complete
- 页码：564-572
- 全文大小：1472 K
文摘
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The full-length cDNA sequence of Cip65 and the promoter sequence of CiIkBα were cloned and identified.
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The expression of Cip65 was ubiquitous and significantly up-regulated after stimulation with poly I:C.
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In vitro, Cip65 polypeptide had affinity with CiIκBα promoter sequence by gel mobility shift assays.
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In vivo cotransfection experiment demonstrated that Cip65 played a positive role in the transcription of CiIkBα.