IL-15 up-regulates the MMP-9 expression levels and induces inflammatory infiltration of macrophages in polymyositis through regulating the NF-kB pathway
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- 作者：Wang Yan ; Weinv Fan ; Caijing Chen ; Yunqin Wu ; Zhenyi Fan ; Jiaqi Chen ; Zhaoying Chen ; Huimin Chen ; chm6420@yeah.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：PM ; Polymyositis ; CK ; creatine kinase ; IL-15 ; Interleukin 15 ; NF-kB ; nuclear factor kappa B ; ECM ; extracellular matrix ; TWEAK ; tumor necrosis factor-related weak inducer of apoptosis
- 刊名：Gene
- 出版年：2016
- 出版时间：10 October 2016
- 年：2016
- 卷：591
- 期：1
- 页码：137-147
- 全文大小：1458 K
文摘
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It is the first time to investigate the relationship between IL-15, MMP-9 and NF-kB pathway in polymyositis.
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Anti-IL-15 and IL-15Rα siRNA play protective effects in polymyositis.
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ERK1/2 pathway plays important role in IL-15 regulating MMP-9 expression.
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IKBα is a important downstream molecule of IL-15/MMP-9 pathway.