Reduced serotonin transporter binding in the insular cortex in patients with obsessive–compulsive disorder: A [¹¹C]DASB PET study

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• 作者：Ryohei Matsumoto ; Masanori Ichise ; Hiroshi Ito ; Tomomichi Ando ; Hidehiko Takahashi ; Yoko Ikoma ; Jun Kosaka ; Ryosuke Arakawa ; Yota Fujimura ; Miho Ota ; Akihiro Takano ; Kenji Fukui ; Kazuhiko Nakayama ; Te
• 关键词：Obsessive– ; compulsive disorder (OCD) ; Positron emission tomography (PET) ; Serotonin transporter ; Insular cortex ; Voxel based analysis
• 刊名：NeuroImage
• 出版年：2010
• 出版时间：1 January 2010
• 年：2010
• 卷：49
• 期：1
• 页码：121-126
• 全文大小：518 K

文摘

The serotonin transporter (5-HTT) and other markers of the serotonergic system have been of interest in the pathophysiology of obsessive-compulsive disorder (OCD). Previous studies using single photon emission computed tomography (SPECT) with [¹²³I]β-CIT or positron emission tomography (PET) with [¹¹C]McN5652 have not shown consistent findings about 5-HTT in OCD patients. The aim of the present study was to investigate 5-HTT binding using [¹¹C]DASB, which has higher selectivity or specific binding-to-nonspecific binding ratios for 5-HTT compared to the aforementioned radioligands. Four drug-naive and 6 drug-free patients with OCD who were free of comorbid depression and 18 gender and age-matched healthy subjects underwent PET scans with [¹¹C]DASB. The severity of OCD was assessed by Yale–Brown Obsessive–Compulsive Scale (Y-BOCS) (mean ± SD: 22 ± 7.6, range: 7–32). The binding potential (BP_ND) of [¹¹C]DASB was calculated using a two-parameter multilinear reference tissue model (MRTM2). The parametric images of BP_ND were analyzed using a statistical parametric mapping system. Significant reductions of BP_ND were observed in the right posterior and left anterior insular cortices in patients with OCD compared to controls. Region-of-interest analysis has also confirmed significant reduction of BP_ND in the insular cortex. Although significantly reduced BP_ND in the orbitofrontal cortex was also observed in patients with OCD compared to controls, this finding should be considered with caution because of the very low 5-HTT binding in the region. On the other hand, no significant correlation was observed between the Y-BOCS score and BP_ND. The change in [¹¹C]DASB binding in the insular cortex suggests that dysfunction of the serotonergic system in the limbic area might be involved in the pathophysiology of OCD.