Genetic variants in IL-6 and IL-10 genes and susceptibility to hepatocellular carcinoma in HCV infected patients

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• 作者：Ikram Sghaier^a ; ^{sghaiere.ikram@gmail.com} ; Leila Mouelhi^b ; Noor A. Rabia^c ; Bano R. Alsaleh^c ; Ezzedine Ghazoueni^d ; Wassim Y. Almawi^c ; Besma Yacoubi Loueslati^a
• 关键词：Hepatitis C virus ; Hepatocellular carcinoma ; IL-6 ; IL-10
• 刊名：Cytokine
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：89
• 期：Complete
• 页码：62-67
• 全文大小：680 K
• 卷排序：89

文摘

IL-10 rs1800871, rs1800872, and rs1878672 variants were associated with HCV outcome. High IL-6 levels in HCV infected patients are associated with disease progression. IL-6 rs1800796 variant was associated with hepatocellular carcinoma. IL-10 and IL-6 SNPs markedly influence the clinical outcomes of HCV infection.