Oral exposure to Listeria monocytogenes in aged IL-17RKO mice: A possible murine model to study listeriosis in susceptible populations
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- 作者：Mohammad S. Alam ; Mohammad.alam@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author ; Matthew Costales1 ; Christopher Cavanaugh ; Marion Pereira ; Dennis Gaines ; Kristina Williams
- 关键词：Listeria monocytogenes ; Aging ; IL17RA-KO mice ; Immune-dysregulation ; T helper-cells
- 刊名：Microbial Pathogenesis
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：99
- 期：Complete
- 页码：236-246
- 全文大小：2735 K
文摘
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Aged IL17R-KO mice as potential surrogate for studying Listeriosis in humans.
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Aged mice are more susceptible to oral infection with Listeria monocytogenes.
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Listeriosis in aged mice is associated with imbalance in Th1/Th2 responses.
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Antilisterial Th1 responses can be affected by higher Treg cells in aged mice.