Human kidney damage in fatal dengue hemorrhagic fever results of glomeruli injury mainly induced by IL17
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- 作者：Carla Pagliaria ; b ; Juarez Antô ; nio Simõ ; es Quaresmac ; d ; Luciane Kanashiro-Galoa ; Leda Viegas de Carvalhoe ; Webster Oliveira Vitoriab ; Wellington Luiz Ferreira da Silvaa ; Ricardo Pennye ; Barbara Cristina Baldez Vasconcelosc ; f ; Pedro Fernando da Costa Vasconcelosc ; f ; pedrovasconcelos@iec.pa.gov.br" class="auth_mail" title="E-mail the corresponding author ; pedro.vasconcelos@globo.com" class="auth_mail" title="E-mail the corresponding author ; Maria Irma Seixas Duartea
- 关键词：Dengue ; Kidney ; Immunohistochemistry ; Cells ; Cytokines
- 刊名：Journal of Clinical Virology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：16-20
- 全文大小：1699 K
文摘
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Lymphocytes CD4+ predominated over CD8+ T cells, B cells and natural killer cells.
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An expressive number of macrophagic CD68+ cells were present in dengue kidney tissues.
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Cells expressing IL17 and IL18+ cytokines predominated in the renal tissues.
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Cells showing IL17 and IL18+ reflect the acute inflammatory response and local lesion.
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Human kidney damage in fatal severe dengue results of glomeruli injury induced by IL17.