Hypocretin/orexin loss changes the hypothalamic immune response
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- 作者：Susumu Tanakaa ; b ; tanakass@hirakata.kmu.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Nae Takizawaa ; Yoshiko Hondab ; Taro Koikea ; Souichi Oea ; Hiromi Toyodab ; c ; Tohru Kodamab ; Hisao Yamadaa
- 关键词：Aoc1 ; amine oxidase ; copper containing 1 ; B2m ; beta-2 microglobulin ; Cox2 ; cyclooxygenase-2 ; Csf3 ; colony stimulating factor 3 ; Cxcl15 ; chemokine (C-X-C motif) ligand 15 ; Gapdh ; glyceraldehyde-3-phosphate dehydrogenase ; Hcrt ; hypocretin ; Hdc ; histidine decarboxylase ; Hnmt ; histamine N-methyltransferase ; Ifng ; interferon gamma ; Il10 ; interleukin 10 ; Il18 ; interleukin 18 ; Il1b ; interleukin 1 beta ; Il1rn ; interleukin 1 receptor antagonist ; Il6 ; interleukin 6 ; Il8 ; interleukin 8 ; LPS ; lipopolysaccha
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：57
- 期：Complete
- 页码：58-67
- 全文大小：970 K
文摘
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LPS induced-hypothalamic immune response was altered by hypocretin loss.
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Hypocretin expression was completely abolished by LPS in hypocretin/ataxin-3 mice.
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An increase in HDC cells and Hdc was found in hypocretin/ataxin-3 mice.
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Hypocretin loss did impact the change in Ifng and Csf3.
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c-Fos-positive/HDC cells in hypocretin/ataxin-3 mice was elevated by LPS.