Circulating T follicular helper cells are associated with rapid virological response in chronic hepatitis C patients undergoing peginterferon therapy
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- 作者：Miao Zhang1 ; Li Zhang1 ; Hu Li ; Zhiwei Chen ; Aoran Luo ; Bin Liu ; Min Chen ; Mingli Peng ; Hong Ren ; Peng Hu ; hp_cq@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：T follicular helper cells ; B cells ; Cytokines ; Hepatitis C virus ; Interferon ; PD-1
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：34
- 期：Complete
- 页码：235-243
- 全文大小：1272 K
文摘
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T follicular helper cells and surface molecules (ICOS, PD-1, CD40L, IL21R) were higher in chronic hepatitis C patients.
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Memory B cell frequency may just be associated with liver fibrosis.
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Plasma levels of Th cell cytokines were higher in CHC, except for IL-21.
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A higher frequency of TFH cells existed in rapid virological responders with PEG-IFNα-based therapy.