A two-clones tumor model: Spontaneous growth and response to treatment
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文摘

Two (or more) growing cancer cell populations limit each other by sharing a finite amount of physical and energetic resources (carrying capacity). For instance, it may explain the revival of metastasis from the dormancy following the primary tumor excision.

The growth models corresponding to the different order of the Phenomenological Universalities can be applied to many biological cases, accounting for different behaviors and predicting a larger variety of dynamical phase space plots.

Therapies may impact on different population growths inducing mutations and resistant clones as well as rebalancing their resources availability.

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