Proteomic changes in the ileum of sheep infected with Mycobacterium avium subspecies paratuberculosis

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• 作者：S. Pisanu^a ; T. Cubeddu^b ; S. Uzzau^a ; ^c ; S. Rocca^b ; M.F. Addis^a ; ^{addis@portocontericerche.it}
• 关键词：Mycobacterium avium subspecies paratuberculosis ; Johne's disease ; Ovine ; Mass spectrometry ; Proteomics
• 刊名：The Veterinary Journal
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：219
• 期：Complete
• 页码：1-3
• 全文大小：188 K
• 卷排序：219

文摘

Johne's disease (JD) is caused by Mycobacterium avium subsp. paratuberculosis (MAP) and has an economic impact on sheep productions. A shotgun proteomics study was carried out on terminal ileum tissues from infected and uninfected ewes. A large data set of proteomic changes occurring in the infected ileum was generated and analysed. MAP proteins highly expressed in vivo in the infected tissue were identified. The proteins undergoing the most relevant changes are related to host immune response and MAP pathogenesis.