Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds
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- 作者：Bü ; nyamin Ö ; zgerişa ; b ; Sü ; leyman Gö ; ksub ; sgoksu@atauni.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Leyla Polat Kö ; seb ; İlhami Gü ; lç ; inb ; c ; igulcin@atauni.edu.tr" class="auth_mail" title="E-mail the corresponding author ; Ramin Ekhteiari Salmasd ; Serdar Durdagid ; Ferhan Tü ; mere ; Claudiu T. Supuranf ; g
- 关键词：Acetylcholine esterase ; Carbonic anhydrase ; Enzyme inhibition ; Sulfamide ; Urea ; Molecular docking ; Molecular dynamics (MD) simulations
- 刊名：Bioorganic & Medicinal Chemistry
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：24
- 期：10
- 页码：2318-2329
- 全文大小：2380 K
文摘
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Three novel sulfamides derived from 2-aminotetralins were synthesized.
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Three novel ureas derived from 2-aminotetralins were synthesized.
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Synthesized sulfamide and ureas were converted to their phenolic derivatives.
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The compounds showed effective hCA I, II and AChE inhibition.
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The molecular mechanisms of inhibitions were investigated by in silico studies.