Therapeutic plasma-exchange in hematologic disease: Results from a single center in Eastern Anatolia

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• 作者：Mehmet Ali Erkurt ; ^{erkurtali@hotmail.com} ; Irfan Kuku ; Emin Kaya ; Unsal Ozgen ; Ilhami Berber ; Mustafa Koroglu ; Mustafa Ozg&uuml ; l
• 关键词：Therapeutic plasma exchange ; Plasmapheresis ; Adverse events
• 刊名：Transfusion and Apheresis Science
• 出版年：2013
• 出版时间：June, 2013
• 年：2013
• 卷：48
• 期：3
• 页码：335-339
• 全文大小：220 K

文摘

Therapeutic plasma-exchange (TPE) is used as primary and adjunctive therapy in treatment of several hematologic diseases. We retrospectively evaluated the results of TPE in hematologic diseases during 2008-2012. A total of 301 TPE procedures were performed in 44 patients (19 male and 25 female, with mean age of 50.6 ¡À 15 years). Fifteen of 44 patients had thrombotic thrombocytopenic purpura (TTP), 14 patients had HELLP syndrome (Hemolysis Elevated Liver enzymes, Low Platelet count), 10 patients had multiple myeloma-hyperviscosity and the rest five patients had snake bite. Fresh frozen plasma (FFP) was used as replacement fluid. Complete response (CR) was achieved on 13 patients (87 % ) in primarily TTP. CR was achieved in all other three diseases. Total complications were detected in 8.1 % of the TPE procedures. Adverse events (AEs), were seen in 5.4 % of all procedures. None of the patients died from any complication. AE occurred in 4 % (Grade-I), 1 % (Grade-II), and 0.3 % (Grade-III) of the procedures. The most common AE were nausea/vomiting, hypotension, pruritus and abdominal pain. TPE is effectively and safely carried out in our center in hematologic diseases.