T-waves inversion in patients with clinically suspected acute myocarditis showed a significant association with transmural myocardial edema as evidenced by CMR T2-weighted sequences.
T-waves normalized in all patients and the presence of TWI during acute phase was not an unfavorable predictor of LV systolic dysfunction at 6-month period of follow-up.
A possible interpretation of these findings is that, as an expression of reversible myocardial edema, TWI during the acute phase of myocarditis does not represent a marker of adverse prognosis because it reflects a transient impairment of myocardial function.