The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression
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- 作者：Elizabeth J. Videlocka ; evidelock@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Wendy Shihb ; wshih3737@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mopelola Adeyemoa ; maadeyemo@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Swapna Mahurkar-Joshia ; swapnajoshi@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Angela P. Pressonc ; angela.presson@hsc.utah.edu" class="auth_mail" title="E-mail the corresponding author ; Christos Polytarchoua ; cpolytarchou@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Melissa Albertoa ; melissa.alberto3@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Dimitrios Iliopoulosa ; diliopoulos@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Emeran A. Mayera ; emayer@ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Lin Changa ; linchang@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Irritable bowel syndrome ; Hypothalamic pituitary-regulating hormones ; Adrenal cortex hormones ; Glucocorticoids receptors ; Sex differences
- 刊名：Psychoneuroendocrinology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：69
- 期：Complete
- 页码：67-76
- 全文大小：1631 K
文摘
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Cortisol response to ACTH is affected by sex and irritable bowel syndrome (IBS).
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Response is increased in men but blunted in women with IBS compared to controls.
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Glucocorticoid receptor α (GRα) mRNA is reduced in IBS and negatively correlates with ACTH response.
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Low expression of GRα is associated with increased symptom severity in IBS.