Clinically relevant concentration of pregabalin has no acute inhibitory effect on excitation of dorsal horn neurons under normal or neuropathic pain conditions: An intracellular calcium-imaging study in spinal cord slices from adult rats
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- 作者：Hiroshi Babaa ; baba@med.niigata-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Andrey B. Petrenkoa ; Naoshi Fujiwarab
- 关键词：Ca2+-imaging ; Pregabalin ; Clinically relevant concentration ; Acute effect ; Spinal cord ; Diabetic neuropathic rat
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 October 2016
- 年：2016
- 卷：1648
- 期：part_PA
- 页码：445-458
- 全文大小：2969 K
文摘
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Ca2+-imaging was used to study the spinal effect of pregabalin in adult rats.
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Clinically relevant concentration of pregabalin had no acute inhibitory effect.
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Extremely high concentration of pregabalin slightly inhibited neuronal activity.
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The effects of pregabalin were similar in normal and diabetic neuropathic rats.
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Acute spinal effect of pregabalin may not be its main analgesic mechanism.