Utilizing fluorescent life time imaging microscopy technology for identify carriers of BRCA2 mutation
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- 作者：Tamar Zahavia ; b ; 1 ; Gilad Yahavc ; 1 ; Yael Shimshonb ; Sivan Gershanovb ; Luna Kaduria ; Amir Sonnenblicka ; Dror Fixlerc ; Asher Y. Salmona ; Mali Salmon-Divonb ; malisa@ariel.ac.il" class="auth_mail" title="E-mail the corresponding author
- 关键词：BRCA1 ; BRCA2 ; FLIM ; Irradiation
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：4 November 2016
- 年：2016
- 卷：480
- 期：1
- 页码：36-41
- 全文大小：948 K
文摘
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Fluorescent lifetime imaging microscopy (FLIM) technology can be used for recognizing BRCA mutation carriers.
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Cells originated from BRCA2-mutation carriers have lower FLT values compared with BRCA1 mutation carriers and control cells.
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The difference in FLT values were observed regardless irradiation.
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FLIM method may be more informative in the detection of BRCA2-mutation carriers than BRCA1.