New pyridoxal based chemosensor for selective detection of Zn²⁺: Application in live cell imaging and phosphatase activity response

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• 作者：Senjuti Mandal^a ; Yeasin Sikdar^a ; Dilip K. Maiti^a ; Ria Sanyal^a ; Debasis Das^a ; Abhishek Mukherjee^b ; Sushil Kumar Mandal^c ; Jayanta Kumar Biswas^c ; Antonio Bauzá ; ^d ; Antonio Frontera^d ; Sanchita Goswami^a ; ^{sgchem@caluniv.ac.in}
• 关键词：Chemosensor ; Schiff base ; Fluorimetry ; Live cell imaging ; Phosphatase activity ; DFT
• 刊名：Journal of Photochemistry and Photobiology A: Chemistry
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：334
• 期：Complete
• 页码：86-100
• 全文大小：3552 K
• 卷排序：334

文摘

A simple Schiff base ligand was synthesized and characterized which shows turn-on response for Zn(II). The experimental and theoretical supports in terms of 1H and 13C NMR spectroscopy and DFT/TDDFT study are provided to establish the binding mode of H4PydChda to Zn2+. The resulting Zn(II) complex shows convincing phosphatase activity (kcat = 21.59 s−1).