Effect of adrenalectomy on IgA production in the large intestine of BALB/c mice

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• 作者：A. Resendiz Albor^a ; A. Garc&iacute ; a-Fonseca^a ; I. Arciniega-Martinez^a ; M. Salas-Pimentel^a ; E. Mart&iacute ; nez-Becerril^a ; R. Campos-Rodr&iacute ; guez^a ; ^b
• 刊名：Brain, Behavior, and Immunity
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：49
• 期：supp_S
• 页码：e34-e35
• 全文大小：46 K

文摘

Nervous System in coordination with an other systems as endocrine and immune. Several studies have shown that conditions of stress modify the expression and concentration of SIgA, which has been attributed to factors as glucocorticoids and catecholamines produced in the adrenal gland. The objective of this study was determined the effect of adrenalectomy on secretion of IgA in the large intestine of BALB/c mice under acute stress by immobilization. We determined the concentration of serum corticosterone by RIA, the concentration of SIgA in intestinal fluid by ELISA and the percentage of T CD4+, T CD8+, B lymphocytes and plasma cells IgA+ in lamina propria by flow cytometry. The results showed that the serum corticosterone in the group SHAM+stress increased due to the effect of the activation of the hypothalamic-pituitary-adrenal axis and the concentration of SIgA. Regarding the cellular percentage, we founded an increased percentage of lymphocytes B and plasma cells positives to IgA; due to the effect of glucocorticoids and catecholamines over the cells of the immune system. The concentration of SIgA in intestinal fluid decreased compared to the SHAM group. Stress showed an important decreased on SIgA levels in comparison with SHAM+E group. We can conclude that the suppression of cortisol and catecholamines with acute exposure to stress directly affects the immune status in the large intestine. This work was supported by SIP-COFAA-IPN.