Inducing a humoral immune response to pancreatic cancer antigen

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• 作者：Michael Seifert ; MD ; ¹ ; ^{michael.seifert@uniklinik-freiburg.de} ; Gabriel Seifert ; MD¹ ; Guido Wolff-Vorbeck ; PhD ; Elia Langenmair ; MD ; Ulrich T. Hopt ; MD ; Uwe A. Wittel ; MD
• 关键词：CD ; cluster of differentiation ; EDTA ; ethylenediaminetetraacetic acid ; EGFR ; epidermal growth factor receptor ; ELISA ; enzyme-Linked Immunosorbent Assay ; Fcγ ; fragment crystallizable region ; HRP ; horseradish peroxidase ; IgG ; immunoglobulin G ; IgM ; immunoglobulin M ; IL ; interleukin ; mAb ; monoclonal antibody ; PBMC ; peripheral blood mononuclear cell ; PDAC ; pancreatic ductal adenocarcinoma ; PMF ; plasma membrane fragment ; pNPP ; para-Nitrophenylphosphate
• 刊名：Cellular Immunology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：310
• 期：Complete
• 页码：150-155
• 全文大小：429 K
• 卷排序：310

文摘

The novel method presented elicits a human IgG response to tumor antigens in vitro. Pancreas cancer cell (PANC-1) antigens can induce such anti-tumor antibodies. This response has the potential to generate antibodies specific to PANC-1 antigens. Pancreas cell line BxPC3 suppresses such an IgG response. This study underlines the importance of personalized tumor approaches.