Oral vaccination with a rough attenuated mutant of S. Infantis increases post-wean weight gain and prevents clinical signs of salmonellosis in S. Typhimurium challenged pigs
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- 作者：Neil Fostera ; n.foster@nottingham.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Luke Richardsa ; John Higginsa ; Theo Kanellosb ; Paul Barrowa
- 关键词：Salmonella ; Pigs ; Serogroup ; Vaccine ; Innate immunity ; Weight gain
- 刊名：Research in Veterinary Science
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：104
- 期：Complete
- 页码：152-159
- 全文大小：987 K
文摘
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Infection of pigs withS.Typhimurium results in significant reduction in weight gain up to 14 days post-weaning.
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Vaccination of pigs with a rough mutantS.Infantis prevents weight gain loss when challenged withS.Typhimurium.
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Thus S. Infantis vaccination protects against a different Salmonella serogroup.
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Severe ileal lesions associated with S. Typhimurium infection are abbrogated by pre-inoculation with S. Infantis.
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S. Infantis gave some protection against E. coli but unrelated M. bovis BCG gave no protection against S. Typhimurium.