Autoantibodies to asialoglycoprotein receptor (ASGPR) in patients with autoimmune liver diseases
详细信息 查看全文
- 作者：Danilo Villaltaa ; Maria G. Mytilinaioub ; Martina Elsnerc ; Christian Hentschelc ; Juliane Cuccatoc ; Valentina Sommac ; Peter Schierackd ; Dirk Roggenbuckc ; d ; 1 ; dirk.roggenbuck@b-tu.de" class="auth_mail" title="E-mail the corresponding author ; Dimitrios P. Bogdanosb ; e ; 1
- 关键词：Ab(s) ; autoantibody(ies) ; AIH ; autoimmune hepatitis ; AIH-1 ; autoimmune hepatitis type 1 ; AIH-2 ; autoimmune hepatitis type 2 ; ALD ; autoimmune liver disease ; AMA ; antimitochondrial antibody ; ANA ; antinuclear antibody ; ASGPR ; asialoglycoprotein receptor ; BD ; blood donors ; CI ; confidence interval ; CLD ; cryptogenic liver disease ; CV ; coefficient of variation ; ELISA ; enzyme-linked immunosorbent assay ; HCV ; hepatitis C virus ; LC-1 ; liver-cytosol type 1 antibody ; LIA ; line immunoassay ; IIF ; indirect imm
- 刊名：Clinica Chimica Acta
- 出版年：2015
- 出版时间：23 October 2015
- 年：2015
- 卷：450
- 期：Complete
- 页码：1-5
- 全文大小：357 K
文摘
- •
The ELISA with highly purified rabbit ASGPR can be used as a complementary test for autoimmune liver disease serology.
- •
The Anti-ASGPR ELISA is well suited for routine laboratories basing their Ab testing on solid-phase enzyme immunoassays.
- •
Individuals with clinical suspicion of AIH and seronegative conventional AIH-related Abs should to be screened for ASGPR Abs.
- •
ASGPR Abs can be found in patients with AIH as the only disease-related autoantibody.
- •
The high prevalence of ASGPR Abs in patients with PSC needs to be corroborated by further studies.