Unfolded protein response in hypothalamic cultures of wild-type and ATF6α-knockout mice
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- 作者：Wenjun Lua ; Daisuke Hagiwaraa ; d-hagiwara@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yoshiaki Morishitaa ; yoshi214@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Masayoshi Tochiyaa ; Yoshinori Azumaa ; Hidetaka Sugaa ; Motomitsu Gotoa ; Ryoichi Bannoa ; Yoshihisa Sugimuraa ; Seiichi Oyadomarib ; Kazutoshi Moric ; Hiroshi Arimaa ; arima105@med.nagoya-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ER ; endoplasmic reticulum ; UPR ; unfolded protein response ; IRE1 ; inositol requiring enzyme 1 ; PERK ; protein kinase RNA-like ER kinase ; ATF6α ; activating transcription factor 6α ; XBP1 ; X-box binding protein 1 ; eIF2α ; eukaryotic translation initiation factor 2α ; ATF4 ; activating transcription factor 4 ; CHOP ; C/EBP homologous protein ; BiP ; immunoglobulin heavy chain binding protein ; ERAD ; ER-associated degradation ; ERAC ; ER-associated compartment ; FNDI ; familial neurohypophysial diabetes insipidus
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：26 January 2016
- 年：2016
- 卷：612
- 期：Complete
- 页码：199-203
- 全文大小：749 K
文摘
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Thapsigargin (TG) activated all the UPR arms similarly in mouse hypothalamic cultures.
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TG-induced upregulation of BiP and CHOP was attenuated in ATF6α−/− mouse hypothalamus.
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TG-induced upregulation of ERAD components was also attenuated in ATF6α−/− mouse hypothalamus.