SIRP/CD47 signaling in neurological disorders
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- 作者：Haiyue Zhanga ; c ; Fengwu Lib ; Yuanyuan Yanga ; c ; Jun Chena ; chenj2@upmc.edu" class="auth_mail" title="E-mail the corresponding author ; Xiaoming Hua ; b ; hux2@upmc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：A尾 ; amyloid 尾 ; AD ; Alzheimer壮s disease ; CNS ; central nervous system ; IgSF ; immunoglobulin superfamily ; ICH ; inintracerebral hemorrhage ; DAP12 ; DNAX activation protein 12 ; ITAM ; immunoreceptor tyrosine-based activation motif ; ITIM ; immunoreceptor tyrosine-based inhibition motif ; MAPK ; mitogen-activated protein kinase ; MMP ; matrix metalloproteinase ; MS ; multiple sclerosis ; NO ; nitric oxide ; ROS ; reactive oxygen species ; SCI ; spinal cord injury ; SHP1 ; SH2 domain-containing phosphatase-1 ; (SIRP) ; Si
- 刊名：Brain Research
- 出版年：2015
- 出版时间：14 October 2015
- 年：2015
- 卷：1623
- 期：Complete
- 页码：74-80
- 全文大小：641 K
文摘
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SIRP and CD47 regulate microglial activation.
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SIRP and CD47 mediate the interplay between microglia and other CNS cells.
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CD47 and SIRP伪 are important in neuroinflammation in the CNS disorders.
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CD47 and SIRP伪 may play janus roles in certain pathological events.
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Modulating CD47/SIRP伪 may have different effects depending on disease progress.