Expression regulation of co-inhibitory molecules on human natural killer cells in response to cytokine stimulations
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- 作者：Haoyu Sun ; Cheng Sun ; Weihua Xiao
- 关键词：NK cell ; natural killer cell ; IL ; interleukin ; IFN-伪 ; interferon-伪 ; TGF-尾 ; tumor growth factor-尾 ; PD-1 ; programmed death-1 ; LAG-3 ; lymphocyte activation gene-3 ; TIGIT ; T cell immunoglobulin and ITIM domain ; MHC ; major histocompatibility complex ; LAP ; LAG-3-associated protein
- 刊名：Cytokine
- 出版年：January, 2014
- 年：2014
- 卷：65
- 期：1
- 页码：33-41
- 全文大小：1757 K
文摘
Co-inhibitory molecules have become the key targets in cancer immunotherapy with the strategy of blocking immune checkpoints to reverse the pathogenic regulation of T cells. However, their expression regulations in NK cells, the most important innate immune cells against tumor, remain largely undefined. In this study, we showed that the expressions of co-inhibitors on NK cells, including LAG-3, PD-1, and TIGIT, are differently regulated by cytokines IL-10, IL-12, IL-15, IFN-伪, and TGF-尾. Among the tested cytokines, IL-12 is the most powerful inducer of LAG-3, and TGF-尾 is the strongest suppresser of PD-1. Notably, the expression of these co-inhibitors responds to the time course of stimulus progressively. Together, these findings illustrated that the co-inhibitors on NK cells express differently in response to cytokine stimulations of IL-10, IL-12, IL-15, IFN-伪, and TGF-尾, providing an initial information on the expression regulation of co-inhibitors in human NK cells.