Evolution of Hematopoietic Cell Transplantation for Immunoglobulin Light Chain Amyloidosis

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• 作者：Taimur Sher ; ^{Sher.taimur@mayo.edu" class="auth_mail" title="E-mail the corresponding author} ; Angela Dispenzieri ; Morie A. Gertz
• 关键词：Immunoglobulin light chain amyloidosis ; AL amyloidosis ; Stem cell transplantation ; Hematopoeitic stem cell transplantation
• 刊名：Biology of Blood and Marrow Transplantation
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：22
• 期：5
• 页码：796-801
• 全文大小：379 K

文摘

Immunoglobulin light chain amyloidosis is the most common type of systemic amyloidosis. Hematopoietic stem cell transplantation (HCT) is an effective treatment option for AL however due to multi-organ involvement in this disease HCT is feasible in a minority of patients. To maximize the benefit and minimize toxicity it is of paramount importance to optimize the selection of patients for HCT. In this review we discuss evolution of HCT and its typical application to a case of AL amyloidosis.