Diets containing different fermentable substrates can affect mucosal and systemic immune parameters in rats under homeostatic conditions
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- 作者：Padmaja Shastria ; Justin L. McCarvillea ; Stephen P.J. Brooksb ; Martin Kalmokoffc ; Julia M. Green-Johnsona ; julia.green-johnson@uoit.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：WB ; Wheat bran ; OB ; Oat bran ; RS ; Resistant starch ; IEC ; Intestinal epithelial cells ; TGF-β ; Transforming growth factor(β) ; CINC ; Cytokine induced chemoattractant ; IL ; Interleukin ; PRR ; Pathogen recognition receptor ; TLR ; Toll like receptor ; IgA ; Immunoglobulin A ; MLN ; Mesenteric lymph node ; SCFA ; Short chain fatty acid ; BCFA ; Branched chain fatty acid
- 刊名：Journal of Functional Foods
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：20
- 期：Complete
- 页码：422-432
- 全文大小：1337 K
文摘
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Immune effects varied with diet and tissue examined.
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A wheat bran-containing diet increased levels of IL-10 in the ileum of male rats and spleen of female rats.
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Diets containing oat bran or resistant starch induced pro-inflammatory cytokine profiles in the colon and MLN, respectively.
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Oat bran and resistant starch heightened levels of the regulatory cytokine TGF-β1 in the liver under resting conditions.