Chicken egg yolk antibodies (IgY) modulate the intestinal mucosal immune response in a mouse model of Salmonella typhimurium infection
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- 作者：Xiaoyu Lia ; b ; Ying Yaoa ; Xitao Wanga ; Yuhong Zhenc ; Philip A. Thackerd ; Lili Wanga ; b ; Ming Shie ; Junjun Zhaof ; Ying Zonga ; Ni Wanga ; Yongping Xua ; b ; xiaoyuli@dlut.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：FBS ; fetal bovine serum ; FITC ; fluorescein isothiocyanate ; GALT ; gut-associated lymphoid tissue ; HE ; hematoxylin and eosin ; IgY ; immunoglobulin Y ; IFN-γ ; interferon-γ ; IL ; interleukin ; PBS ; phosphate buffered saline ; PE ; phycoerythrin ; TNF-α ; tumor necrosis factor-α
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：305-314
- 全文大小：1887 K
文摘
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Specific IgY could effectively alleviate S. typhimurium-inflicted damage to the jejunum.
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Specific IgY attenuated an increase in the cytokines IFN-γ and TNF-α in the mucosa.
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IgY attenuated changes in lymphocyte numbers in Peyer's patches, epithelium and lamina propria.
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Specific IgY has an important immune-modulatory role on the intestinal mucosal immune response.
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Specific IgY limits the consequences of intestinal inflammation induced by S. typhimurium.