B cells and their role in the teleost gut
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- 作者：David Parraa ; 1 ; david.parra@uab.cat" class="auth_mail" title="E-mail the corresponding author ; Tomá ; &scaron ; Korytá ; řb ; 1 ; Fumio Takizawab ; J. Oriol Sunyerb ; sunyer@vet.upenn.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Teleost fish ; B cells ; IgT ; Mucosal immunity ; Gut ; GALT
- 刊名：Developmental & Comparative Immunology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：64
- 期：Complete
- 页码：150-166
- 全文大小：1118 K
文摘
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Pathogen infection in the gut induces an accumulation of GALT IgT+ B cells and the secretion of specific IgT in the gut mucus.
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Intestinal microbiota is coated by secretory immunoglobulins, which are transported to the gut lumen by pIgR receptors.
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The induction of mucosal immunoglobulin response upon vaccination is largely unknown.
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The key roles of mucosal B lymphocytes in intestinal homeostasis are conserved throughout evolution.