Measuring local immunoglobulin E in the inferior turbinate nasal mucosa in patients with allergic rhinitis

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• 作者：Yasushi Ota^a ; ^{yasushiota5610@yahoo.co.jp" class="auth_mail" title="E-mail the corresponding author} ; Yoshihiro Ikemiyagi^a ; Toshiya Sato^b ; Tatsuo Funakoshi^c ; Nobuyuki Hiruta^d ; Makoto Kitamura^d ; Hideaki Bujo^b ; Mitsuya Suzuki^a
• 关键词：AlaSTAT 3gAllergy assay ; Cedar pollen ; House dust ; Local allergic rhinitis ; Mites
• 刊名：Allergology International
• 出版年：2016
• 出版时间：October 2016
• 年：2016
• 卷：65
• 期：4
• 页码：396-399
• 全文大小：1009 K

文摘

Studies show that immunoglobulin E (IgE) is produced in the local nasal mucosa in allergic rhinitis patients. However, no study involved the measurement of IgE levels in the local nasal mucosal tissue in allergic rhinitis patients. This study aimed to measure the local IgE levels in the nasal mucosal tissue and to compare the levels of total IgE and specific IgEs in the serum and the inferior turbinate nasal mucosa in allergic rhinitis patients using the AlaSTAT 3gAllergy assay (Siemens Healthcare Diagnostics AG, Erlangen, Germany).

Methods

Total IgE antibodies and allergen-specific IgE antibodies in each sample of nasal mucosal tissue from 11 allergic rhinitis patients were measured with the AlaSTAT 3gAllergy assay. We compared the levels of total IgE and IgEs specific for house dust (HD), mites, and cedar pollen in the serum and the inferior turbinate.

Results

The total IgE levels and the cedar pollen-specific IgE levels in the inferior turbinate mucosal tissue correlated significantly with their respective levels in serum. The HD- and mite-specific IgE levels in the inferior turbinate mucosal tissue did not correlate significantly with their respective levels in the serum.

Conclusions

Our results evaluating the correlations between nasal mucosal and serum levels of antigen-specific IgE indicate that IgE produced in the nasal mucosa affects the IgE levels in the serum, especially the cedar pollen-specific IgE.