Gestation age dependent transfer of human immunoglobulins across placenta in timed-pregnant guinea pigs
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- 作者：Yanqun Xu ; Li Ma ; Malgorzata G. Norton ; Christine Stuart ; Zhong Zhao ; Denise Toibero ; Shelby Dahlen ; Lilin Zhong ; Pei Zhang ; Evi B. Struble ; evi.struble@fda.hhs.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Transplacental immunoglobulin transfer
- 刊名：Placenta
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：36
- 期：12
- 页码：1370-1377
- 全文大小：988 K
文摘
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G. pigs transfer human IgG transplacentally during the third trimester at higher levels than at earlier time-points.
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Both the average fetal concentration and fetal:maternal ratio of human IgG increase in the third trimester.
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In vitro assays with g. pig FcR recapitulate human IgG binding and its internalization by epithelial cells.
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More studies are needed to fully understand FcRn mediated placental transport.