Detection of peanut allergen in human blood after consumption of peanuts is skewed by endogenous immunoglobulins

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• 作者：Lonneke M. JanssenDuijghuijsen^a ; ^b ; ^c ; Harry J. Wichers^a ; Klaske van Norren^b ; Jaap Keijer^c ; Joseph L. Baumert^d ; Govardus A.H. de Jong^e ; Renger F. Witkamp^b ; Stef J. Koppelman^d ; ^{stefkoppelman@zonnet.nl}
• 关键词：Ara h 6 ; peanut allergen ; immunoglobulin G ; ELISA ; inhibition
• 刊名：Journal of Immunological Methods
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：440
• 期：Complete
• 页码：52-57
• 全文大小：492 K
• 卷排序：440

文摘

Peanut allergen can be detected with ELISA in serum after peanut consumption Ara h 6-specific IgG and IgG4 antibodies inhibit detection of Ara h 6 in serum This inhibition may be a broader phenomenon in studies on uptake of food allergens This may explain variable serum levels of food allergen reported in literature