Mucosal tolerance disruption favors disease progression in an extraorbital lacrimal gland excision model of murine dry eye
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- 作者：Mauricio Guzmá ; n ; Irene Keitelman ; Florencia Sabbione ; Analí ; a S. Trevani ; Mirta N. Giordano ; Jeremí ; as G. Galletti ; jeremiasg@gmx.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：Dry eye ; Ocular surface ; Cornea ; Conjunctiva ; Mucosal immunology ; Mucosal tolerance ; Desiccating stress ; Animal models
- 刊名：Experimental Eye Research
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：19-22
- 全文大小：590 K
文摘
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Lacrimal gland excision leads to disruption of ocular mucosal tolerance in mice.
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Th1/Th17 T cells are induced towards an exogenous antigen instead of Tregs.
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Topical NF-κB inhibition prevents this change and reduces corneal epitheliopathy.