Transplantation in the onco-hematology field: Focus on the manipulation of ¦Á¦Â and ¦Ã¦Ä T cells

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• 作者：Nicola Daniele^a ; ^b ; Maria Cristina Scerpa^a ; Maurizio Caniglia^c ; Maria Ester Bernardo^c ; Cecilia Rossi^a ; ^b ; Chiara Ciammetti^a ; ^b ; Giuseppe Palumbo^c ; ^d ; Franco Locatelli^c ; ^d ; ^e ; Giancarlo Isacchi^a ; ^b ; Francesco Zinno^a ; ^b ; ^{zinno@opbg.net} ; ^{francescozinno@virgilio.it}
• 关键词：¦Á¦Â T cells ; ¦Ã¦Ä T cells ; Allogeneic transplantation ; T cell depletion
• 刊名：Pathology - Research and Practice
• 出版年：2012
• 出版时间：15 February 2012
• 年：2012
• 卷：208
• 期：2
• 页码：67-73
• 全文大小：400 K

文摘

¦Ã/¦Ä T cells represent a subset of T cells expressing a T cell receptor (TCR) variant composed of gamma and delta chains. The ¦Ã/¦Ä TCR is expressed by 2-10 % of all T cells in human peripheral blood, whereas the majority of T cells express ¦Á/¦Â TCRs. ¦Ã/¦Ä T cells display a range of innate effector functions including rapid secretion of chemokines and cytokines, as well as target cell lysis. Recent interest has focused on the function of ¦Ã/¦Ä T lymphocytes in allogeneic transplantation in the onco-hematology field. Several studies, in vitro and in vivo, suggest that ¦Ã/¦Ä T lymphocytes are potential beneficial effector cells in the context of hematopoietic stem cell transplantation (HSCT). In addition, in this review, we discuss the depletion of ¦Á/¦Â T lymphocytes in the graft for allogeneic transplantation. In fact, an efficient TCR ¦Á/¦Â cell depletion potentially reduces the risk of GvHD. Furthermore, TCR ¦Á/¦Â T cell depletion, especially with immunomagnetic negative selection, retains other potential beneficial effector cells in the graft, such as ¦Ã/¦Ä T cells, NK cells, and stem cells. These ¡°facilitating?cells might facilitate engraftment, exert GvL effects, and reduce the risk for infections.