Surfactant protein A deficiency exacerbates renal interstitial fibrosis following obstructive injury in mice

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• 作者：Shaojiang Tian^a ; ^b ; ¹ ; ^{sc229@uga.edu} ; Chenxiao Li^a ; ¹ ; Ran Ran^a ; ^b ; Shi-You Chen^a ; ^b ;
• 关键词：SP-A ; surfactant protein A ; UUO ; unilateral ureter obstruction ; HMGB1 ; high mobility group box 1 ; TGF-β ; transforming growth factor β ; BMM ; bone marrow derived-macrophages ; HPTC ; human proximal tubular cell ; qRT-PCR ; Reverse transcription and quantitative RT-PCR ; Co-IP ; co-immunoprecipitation ; α-SMA ; smooth muscle α-actin ; FSP-1 ; fibroblast specific protein 1 ; IL-6 ; Interleukin 6
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1863
• 期：2
• 页码：509-517
• 全文大小：2384 K
• 卷排序：1863

文摘

SP-A is up-regulated in mouse and human kidney epithelium with ureter obstruction. SP-A deficiency exacerbates UUO-caused kidney structural damage and fibrosis in mice. SP-A inhibits HMGB1-mediated myofibroblast activation. SP-A attenuates HMGB1-induced TGF-β expression. SP-A physically interacts with HMGB1.