The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies
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- 作者：Salyan Bhattaraia ; salyan.bhattarai@charite.de" class="auth_mail" title="E-mail the corresponding author ; Khetam Ghannama ; Sabine Krauseb ; Olivier Benvenistec ; Andreas Margd ; Gerjan de Bruine ; Bo-Tao Xine ; Hermen S. Overkleefte ; Simone Spulerd ; 1 ; Werner Stenzelf ; 1 ; Eugen Feista
- 关键词：Idiopathic inflammatory myopathies ; Proteasome ; Immunoproteasome subunits ; Antigen presentation ; Myokine
- 刊名：Journal of Autoimmunity
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：75
- 期：Complete
- 页码：118-129
- 全文大小：6105 K
文摘
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Idiopathic inflammatory myopathies muscle fibers induce immunoproteasome subunits.
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Immunoproteasome inhibition reduce surface expression of MHC-I molecule in myoblast.
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Immunoproteasome inhibition amplify inflammatory mediated myokine expression.