Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells
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- 作者：Olga V. Gvozdevaa ; Alexey A. Belogurov jr.b ; c ; Ekaterina S. Kuzinab ; Alexander G. Gabibovb ; c ; Mariya I. Meschaninovaa ; Alya G. Ven'yaminovaa ; Marina A. Zenkovaa ; Valentin V. Vlassova ; Elena L. Chernolovskayaa ; elena_ch@niboch.nsc.ru" class="auth_mail" title="E-mail the corresponding author
- 关键词：siRNA ; Immunoproteasome ; Chemical modifications ; NSO cells
- 刊名：Biochimie
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：125
- 期：Complete
- 页码：75-82
- 全文大小：1568 K
文摘
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2′-O-methyl modified siRNAs can efficiently silence LMP2, LMP7 and MECL-1 gene expression.
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The mismatches introduced into the 3′ end of the sense strand of the siRNA increased the silencing activity of the siRNAs.
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Incorporation of cholesterol residues into siRNAs is a promising approach for efficient siRNA delivery into cells.