The immunoproteasome in antigen processing and other immunological functions

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• 作者：Michael Basler¹ ; ² ; ^{Michael.Basler@uni-konstanz.de} ; Christopher J Kirk³ ; Marcus Groettrup¹ ; ² ; ^{Marcus.Groettrup@uni-konstanz.de}
• 刊名：Current Opinion in Immunology
• 出版年：2013
• 出版时间：February, 2013
• 年：2013
• 卷：25
• 期：1
• 页码：74-80
• 全文大小：525 K

文摘

Treatment of cells with interferon-¦Ã leads to the replacement of the constitutive catalytic proteasome subunits ¦Â1, ¦Â2, and ¦Â5 by the inducible subunits LMP2 (¦Â1i), MECL-1 (¦Â2i), and LMP7 (¦Â5i), respectively, building the so-called immunoproteasome. The incorporation of these subunits is required for the production of numerous MHC class-I restricted T cell epitopes. Recently, new evidence for an involvement of the immunoproteasome in other facets of the immune response emerged. Investigations of autoimmune diseases in animal models and a genetic predisposition of ¦Â5i in human autoimmune disorders suggest a crucial function of the immunoproteasome in proinflammatory diseases. The recent elucidation of the high-resolution structure of the immunoproteasome will facilitate the design of immunoproteasome selective inhibitors for pharmacological intervention.