An overlooked tumor promoting immunoregulation by non-hematopoietic stromal cells
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- 作者：Anamika Bose ; anamikabose2@gmail.com" class="auth_mail" title="E-mail the corresponding author ; bose_aana@rediffmail.com" class="auth_mail" title="E-mail the corresponding author ; Tithi Ghosh ; Rathindranath Baral
- 关键词：TME ; tumor microenvironment ; NHSC ; non hematopoietic stromal cells ; MSC ; mesenchymal stem cells ; MF ; myofibroblasts ; CAF ; cancer associated fibroblasts PGE2 prostaglandin E2 ; VEC ; vascular endothelial cells ; LEC ; lymphatic endothelial cells ; PDGFR ; platelet derived growth factor receptor ; FAP ; fibroblast activator protein ; LN ; lymph node ; TKI ; tyrosine kinase inhibitors ; IMiDs ; immunomodulatory drugs
- 刊名：Immunology Letters
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：176
- 期：Complete
- 页码：114-121
- 全文大小：1905 K
文摘
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Cancer is a systemic disease comprising multiple components like tumor cells, hematopoietic and non-hematopoietic stromal cells (NHSCs).
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NHSCs constituted by mesenchymal stem cells, pericytes, fibroblsts, adipocytes vascular and lymphatic endothelial cells.
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NHSCs within tumor microenvironment (TME) play a crucial role in cancer progression and metastasis.
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Immunosuppressive role of NHSCs within TME are described in this review which may help in crafting effective cancer management.